The Mookherjee Lab: 

 

at The Manitoba Center for Proteomics &

Systems Biology

Neeloffer Mookherjee_profile  pic_edited

Dr. Neeloffer Mookherjee - Principal Investigator

NMookherjee
NMookherjee

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Hadeesha 2019
Hadeesha 2019

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Dr. Hemshekhar, Postdoctoral Fellow
Dr. Hemshekhar, Postdoctoral Fellow

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NMookherjee
NMookherjee

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Professor, Departments of Internal Medicine and Immunology

CIHR Sex and Gender Science Chair - Circulatory & Respiratory Health

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@NMfromUManitoba

The Mookherjee lab is an inclusive environment, committed to Equity, Diversity and Inclusion.

Dr. Mookherjee is committed to ensuring that everyone is given opportunities to excel in their scholarly activities.

Dr. Mookherjee is current Chair of WISDOM (Women In Science: Development, Outreach & Mentoring)

A Rady Faculty of Health Sciences instituted initiative at The University of Manitoba

Dr. Mookherjee is at the forefront of defining the immunity related functions of cationic host defence (antimicrobial) peptides, and the development of small-peptide based therapeutics for chronic inflammatory diseases.
 

Dr. Mookherjee's current role as a CIHR Sex and Gender Science Chair – Circulatory and Respiratory Health expands the scope of her research program to integrate the impact of sex as a biological variable on respiratory disease progression and response to therapy.

Research Focus:

  • To define molecular processes in the regulation of chronic inflammation, with focus on Cationic Host Defence Peptides (also known as antimicrobial peptides).

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  • To investigate the role of Host Defence Peptides in inflammatory disease such as asthma and arthritis.

  • To develop small synthetic derivatives of host defence peptides, known as Innate Defence Regulator (IDR) Peptides, as immunomodulatory therapy for asthma and arthritis. 

  • To examine regulation of inflammation in chronic inflammatory disease, with focus on asthma and arthritis. 

  • To investigate impact of environmental pollutants of the lung and plasma proteome, in the context of chronic respiratory disease such as asthma.

 

Ongoing Funded Projects (link to project details).

  1. Cytokines and Host Defence Peptides: Mechanisms in regulation of inflammation.

  2. Regulation of airway inflammation and hyperresponsiveness by synthetic innate defence regulator (IDR) peptides.

  3. Mechanisms of sex-related differences in asthma.

  4. Effect of inhaled air pollution on the lung and plasma proteins.

  5. Regulation of inflammatory arthritis by synthetic IDR peptides.​

  6. Other collaborative projects on innate immunity and inflammatory disease.

  7. To define molecular processes in the regulation of chronic inflammation.