The Mookherjee Lab: 

 

at The Manitoba Center for Proteomics &

Systems Biology

Dr. Neeloffer Mookherjee - Principal Investigator

Associate Professor, Dept. Internal Medicine and Immunology

CIHR Sex and Gender Science Chair - Circulatory & Respiratory Health

The Mookherjee lab is an inclusive environment, committed to Equity, Diversity and Inclusion.

Dr. Mookherjee is committed to ensuring that everyone is given opportunities to excel in their scholarly activities.

Dr. Mookherjee is current Chair of WISDOM (Women In Science: Development, Outreach & Mentoring)

A Rady Faculty of Health Sciences instituted initiative at The University of Manitoba

Dr. Mookherjee is at the forefront of defining the immunity related functions of cationic host defence (antimicrobial) peptides, and the development of small-peptide based therapeutics for chronic inflammatory diseases.
 

Dr. Mookherjee's current role as a CIHR Sex and Gender Science Chair – Circulatory and Respiratory Health expands the scope of her research program to integrate the impact of sex as a biological variable on respiratory disease progression and response to therapy.

Research Focus:

  • To define molecular processes in the regulation of chronic inflammation.

  • To define immunity-related functions of Cationic Host Defence Peptides (also known as antimicrobial peptides).

  • To investigate the role of Host Defence Peptides in inflammatory disease such as asthma and arthritis.

  • To develop small synthetic derivatives of host defence peptides, known as Innate Defence Regulator (IDR) Peptides, as immunomodulatory therapy for asthma and arthritis. 

  • To investigate impact of environmental pollutants of the lung and plasma proteome, in the context of chronic respiratory disease such as asthma.

 

Ongoing Funded Projects (link to project details).

  1. Cytokines and Host Defence Peptides: Mechanisms in regulation of inflammation.

  2. Regulation of airway inflammation and hyperresponsiveness by synthetic innate defence regulator (IDR) peptides.

  3. Mechanisms of sex-related differences in asthma.

  4. Effect of inhaled air pollution on the lung and plasma proteins.

  5. Regulation of inflammatory arthritis by synthetic IDR peptides.​

  6. Other collaborative projects on innate immunity and inflammatory disease.

  7. To define molecular processes in the regulation of chronic inflammation.

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© Neeloffer Mookherjee 2020

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